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Stewart
Anderson, PhD
Professor,
Biostatistics
Statistician, NSABP
Education
B.A., University
of Colorado, 1978
M.A., University
of Kansas, 1981
Ph.D., University of Colorado Health
Sciences Center, 1987
Research Interests
Areas of current
methodological research interests include: 1) methods in clinical
trials including survival analysis, Bayesian clinical trials design,
and the use of Markov processes in modeling clinical data; 2) modern
regression techniques especially spline methods and tree-structured
modeling; and 3) general methodology in longitudinal data analysis.
I am also involved
in several large scale collaborative projects. Presently, I am the
primary statistician for seven breast cancer treatment protocols
for the National Surgical Adjuvant Breast and Bowel Project (NSABP)
involving over 10,000 patients. In addition, I am the facilitator
for NSABP for the biannual external Data Monitoring Committee meetings.
In addition to my involvement in breast cancer research, I have
collaborated with Dr. Rolf Loeber, who is the principle investigator
of large prospective study in delinquent boys. Much of this work
involves the analysis of dichotomous and continuous information
which is measured repeatedly over time. (Health
Sciences Faculty Research Interests Project)
Courses
BIOST 2041: Introduction
to Statistical Methods 1
BIOST 2042: Introduction to Statistical
Methods 2
BIOST 2052: Multivariate Analysis
BIOST 2096: Numerical Methods in Biostatistics (http://www.biostat.pitt.edu/biost2096)
Selected Publications
Kelley, M and Anderson, S. Zero inflation in ordinal data: maintaining proportional odds through the use of a mixture model. To appear in Statistics in Medicine (presently online at http://www.interscience.wiley.com).
Rastogi P, Anderson S, Bear H, Geyer C, Kahlenberg M, Robidoux A, Margolese R, Hoehn JL, Vogel V, Dakhil S, Tamkus D, King K, Pajon E, Wright M, Robert J, Mamounas E, Wolmark N Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocols B_18 and B_27. Journal of Clinical Oncology, 28(5), 778-785, February 10, 2008.
Fisher, B. and Anderson, S. Local therapy and survival in breast cancer. New England Journal of Medicine. 357(10), 1051, September 6, 2007
Dang Q, Mazumdar S, Anderson SJ, Houck PR and Reynolds CF. Using Trajectories from a Bivariate Growth Curve as Predictors in a Cox Regression Model. Statistics in Medicine, 26, 800-811, 2007.
Anderson S. Some thoughts on the reporting of adverse events in phase II cancer clinical trials. Journal of Clinical Oncology, 24(24), 3821-3822, 2006.
Bear HD, Anderson S, Smith RE, Geyer CE Mamounas EP, Fisher B, Brown AM, Robidoux A, Margolese R, Kahlenberg MS, Paik S, Soran A, Wickerham1, DL, and Wolmark N. A Trial Testing the Effect of Adding Sequential Preoperative or Postoperative Docetaxel (Taxotere) to Preoperative Doxorubicin and Cyclophosphamide (AC) for Operable Breast Cancer: Results from National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B_27.Journal of Clinical Oncology, 24(13), 2019–2027, 2006.
Wapnir IL, Anderson S, Mamounas EP, Geyer CE, Jeong J_H, Tan_Chiu E, Fisher B, and Wolmark N. Prognosis after IBTR and Locoregional Recurrences in Five NSABP Node_Positive Adjuvant Breast Cancer Trials. Journal of Clinical Oncology, 24(13), 2028–2037, 2006.
Dang Q, Anderson S, Tan L and Mazumdar S. Modeling unequally spaced bivariate growth curve data using a Kalman filter approach. Communications in Statistics, Theory and Methods, 34(8), 1821-1831, 2005.
Mor, MK and Anderson, S. A Bayesian group sequential approach for multiple endpoints. Sequential Analysis, 24, 1-18, 2005.
Fisher ER, Anderson S, Dean S, Dabbs D, Fisher B, Siderits, R, Pritchard, J, Pereira, T, Geyer, C, and Wolmark, N. Solving the dilemma of the immunohistochemical and other methods used for scoring ER and PR receptors in patients with invasive breast cancer. Cancer, 164-173, 2005.
Fisher, B, Jeong JH, Bryant, J, Anderson, S, Dignam, J and Wolmark, N. Treatment of lymph node-negative, estrogen receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. The Lancet, 364, 858-868, 2004.
Smith RE,
Bryant J, DeCillis A, and Anderson S. Acute
Myeloid Leukemia and Myelodysplastic Syndrome After Doxorubicin-Cyclophosphamide
Adjuvant Therapy for Operable Breast Cancer: The National Surgical
Adjuvant Breast and Bowel Project Experience. Journal of Clinical Oncology,
21(7): 1195-1204, 2003.
Fisher, B., Anderson, S., Bryant, J., Margolese,
R.G., Deutsch, M., Fisher, E.R., Jeong, J-H, Wolmark, N. Twenty-year
follow-up of a randomized trial comparing total mastectomy, lumpectomy,
and lumpectomy plus irradiation for the treatment of invasive breast
cancer. N Engl
J Med, 347(16): 1233-1241, 2002.
Fisher B., Jeong, J-H, Anderson S., Bryant J., Fisher E.R., and
Wolmark N. Twenty-five-year
follow-up of a randomized trial comparing radical mastectomy, total
mastectomy, and total mastectomy followed by irradiation. N Engl J Med, 347(8): 567- 575, 2002.
Fisher, E.R., Anderson, S., Tan-Chiu, E., Fisher, B.,
Eaton, L. and Wolmark, N. Fifteen year
prognostic discriminants for invasive breast cancer: NSABP Protocol
B-06. Cancer, 91(8): 1679-1687, 2001.
Fisher, B., Anderson, S., Tan-Chiu, E.,
Wolmark, N., Wickerham, D.L., Fisher, E.R., et al. Tamoxifen
and chemotherapy for axillary node negative, estrogen receptor-negative
breast cancer: findings from the National Surgical Breast and Bowel
Project B-23. Journal of
Clinical Oncology, 19(4): 931-942, 2001.
Fisher, B., Dignam, J., Tan-Chiu, E., Anderson,
S., Fisher, E. and Wolmark, N. Prognosis
and treatment of patients with breast tumors of #1 cm and negative
axillary nodes. Journal of the National Cancer
Institute, 93(2): 112-120, 2001.
Tian,
W. and Anderson, S.J. Markov chain
models for multivariate repeated binary data analysis. Communications in Statistics, Simulation
and Computation, 29(4), 2000.
Fisher,
B., Anderson, S., Decillis, D., Dimitrov, N., et al. Further
evaluation of intensified and increased total dose of cyclophosphamide
for the treatment of primary breast cancer: findings from National
Surgical Adjuvant Breast and Bowel Project B-25. Journal
of Clinical Oncology, 17(11): 3374-3388, 1999.
Smith, R., Brown, A. Mamounas, E.P., Anderson, S.J., Lembersky,
B.C., et al.
A
randomized trial of 3-hour vs 24-hour infusion of high-dose paclitaxel
in patients with metastatic or locally advanced breast cancer: National
Surgical Adjuvant Breast and Bowel Project Protocol B-26. Journal of Clinical Oncology, 17(11): 3403-3411,
1999.
Costantino,
J.P., Gail, M.H., Pee, D., Anderson, S., Redmond, C.K., Benichou,
J. and Wieand, H.S. Validation studies for models to project the risk of invasive
breast cancer and total breast cancer incidence. The Journal of the National Cancer Institute,
91(18):1541-1548, 1999.
Ahnn S, Anderson S. Sample
size determination in complex clinical trials comparing more than
two groups for survival endpoints. Statistics in Medicine, 17:2525-2534, 1998.
Fisher B, Anderson S, Wickerham DL, et al. Increased
intensification and total dose of cyclophosphamide
in a doxorubicin-cyclophosphamide regimen
for the treatment of primary breast cancer: findings from National
Surgical Adjuvant Breast and Bowel Project B-22. Journal of Clinical
Oncology, 15:1858-69, 1997.
Fisher
B, Anderson S, Redmond C, Wolmark N, Wickerham DL, Cronin W. Reanalysis
and results after 12 years of follow-up of a randomized clinical
trial comparing total mastectomy to lumpectomy with and without
irradiation in the treatment of breast cancer. The
New England Journal of Medicine, 333:1456-1461, 1995.
Ahnn S, Anderson SJ. Sample
size calculations for comparing k survival distributions. Statistics in Medicine, 14:2273-2282,
1995.
Anderson SJ and Jones RH. Smoothing
splines for longitudinal data. Statistics in Medicine, 14:1235-1248, 1995.
Fisher B, Anderson
S, Fisher E, Redmond C, et al. The significance
of breast tumor recurrence following lumpectomy for the treatment
of breast cancer: findings from NSABP B-06. The Lancet, 338:327-331, 1991
Anderson SJ, Jones
RH and Swanson GD. Smoothing
polynomial splines for bivariate data. SIAM Journal of Scientific and Statistical
Computing, 11(4), 1990.
Contact Information
302 Parran Hall
130 DeSoto Street
Pittsburgh, PA 15261
Telephone: 412-624-3023
Facsimile: 412-624-2183
Email: sja@pitt.edu
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