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Publications
Methodological work:
  • Yan Lin, George C. Tseng, Soo Yeon Cheong, Lora J.H. Bean, Stephanie L. Sherman, Eleanor Feingold. (2008) Smarter Clustering Methods for SNP Genotype Calling. Bioinformatics. 24:2665-2671.
  • Yu-Shuen Tsai, Chin-Teng Lin, George C. Tseng, I-Fang Chung and Nikhil Ranjan Pal. (2008) Discovery of Dominant and Dormant Genes from Expression Data Using a Novel Generalization of SNR for Multi-class Problems. BMC Bioinformatics. 9:425.
  • George C. Tseng, Chunrong Cheng*, Yan Ping Yu, Joel Nelson, George Michalopoulos and Jian-Hua Luo. (2008)Common Predictive Biomarkers and Cross-predictability in the Expression Profiles of Multiple Cancer Types. Biomarker Insights. (accepted).
  • Guy N. Brock*, John R. Shaffer*, Richard E. Blakesley-Ball*, Meredith J. Lotz*, and George C. Tseng. (2008) Which Missing Value Imputation Method to Use in Expression Profiles: a Comparative Study and Two Selection Schemes. BMC Bioinformatics. 9:12. (PDF)
  • Yingying Huang, George C. Tseng, Shinsheng Yuan, Ljiljana Pasa-Tolic, Mary S. Lipton, Richard D. Smith, Vicki H. Wysocki. (2008). A data mining scheme for identifying peptide structural motifs behind different MS/MS fragmentation intensity patterns. Journal of Proteome Research. 7:70-79. (PDF)
  • George C. Tseng. (2007). Penalized and weighted K-means for clustering with scattered objects and prior information in high-throughput biological data. Bioinformatics. 23:2247-2255. (PDF)
  • Anbupalam Thalamuthu*, Indranil Mukhopadhyay*, Xiaojing Zheng* and George C. Tseng. (2006) Evaluation and comparison of gene clustering methods in microarray analysis. Bioinformatics. 22:2405-2412. (PDF)(simu data) (real data)
  • Wei Wu, Nilesh Dave, George C. Tseng, Thomas Richards, Eric Xing, Naftali Kaminski. (2005). Comparison of normalization methods for CodeLink Bioarray data. BMC Bioinformatics. 6:309. (PDF)
  • George C. Tseng and Wing H. Wong. (2005) Tight Clustering: A Resampling-based Approach for Identifying Stable and Tight Patterns in Data. Biometrics.61:10-16. (PDF) (elected in August 2006 as Fast Breaking Paper in Mathematics by Essential Science Indicators)
  • Xiaotong Shen, George C. Tseng, Xuegong Zhang, and Wing H. Wong. (2003) On psi-Learning. Journal of the American Statistical Association. 98:724-734. (PDF)
  • George C. Tseng, Min-Kyu Oh, Lars Rohlin, James C. Liao, and Wing Hung Wong. (2001) Issues in cDNA microarray analysis: quality filtering, channel normalization, models of variations and assessment of gene effects. Nucleic Acids Research. 29: 2549-2557. (PDF) (announced in 2003 as one of the eight most accessed papers in NAR)
Collaborative work:
  • Yu-Chen Han, Yan P. Yu, George C. Tseng and Jian-Hua Luo. Trypsin and Reduction Method to Prepare DNA from Formalin-Fixed and Paraffin Embedded Samples for Methylation Analysis. Histopathology. (accepted).
  • Hamm JT, Wilson JW, Rastogi P, Lembersky BC, Tseng GC, Song YK, Kim W, Robidoux A, Raymond JM, Kardinal CG, Shalaby IA, Ansari R, Paik S, Geyer CE, Wolmark N. (2008) Gemcitabine/Epirubicin/Paclitaxel as Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: A Phase II Trial of the NSABP Foundation Research Group. Clinical Breast Cancer. 8:257-263.
  • Marina N. Nikiforova, George C. Tseng, David Steward, Donna Diorio, and Yuri E. Nikiforov. (2008) MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility. Journal of Clinical Endocrinology & Metabolism 93:1600-1608.
  • P Limaye, W Bowen, J Luo, GC Tseng, G Michalopoulos.(2008) Mechanisms of HGF and EGF mediated signaling in Transdifferentiation of Rat Hepatocytes to Biliary Epithelium. Hepatology 47:1702-1713.
  • Alfred Guirguis, Esther Elishaev, Sung-hee Oh*, George C. Tseng, Kristin Zorn, Julie A. DeLoia. (2008). Use of Gene Expression Profiles to Stage Concurrent Endometrioid Tumors for the Endometrium and Ovary. Gynecologic Oncology 108:370-376.
  • Yan Yu, Guoying Yu, George C Tseng, Kathleen Cieply, Joel Nelson, Marie Defrances, Reza Zarnegar, George Michalopoulos and Jianhua Luo. (2007). Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Research. 67:8043-50.
  • E.Sibille, J.Su, S.Leman, A.M.Le Guisquet, Y.Ibarguen-Vargas, J.Joeyen-Waldorf, C.A. Glorioso, G.C.Tseng, M.Pezzone, R.Hen, C.Belzung. (2007) Reduced longevity and anticipated brain molecular aging in mice lacking the serotonin-1B receptor. Molecular Psychiatry. 12:1042-1056.
  • Baoguo Ren, Yan Yu, George C. Tseng, Chuanyue Wu, Ka Chen, Uma Rao, Joel Nelson, George Michalopoulos, and Jian-Hua Luo. (2007). Analysis of Integrin alpha-7 Mutations in Prostate Cancer, Liver Cancer, Glioblastoma Multiforme, and Leiomyosarcoma. JNCI. 99:868-80.
  • C.E. Lagoa, J. Bartels, A. Barratt, G.C. Tseng , G. Clermont, M.P. Fink, T.R. Billiar, Y. Vodovotz. (2006) The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock. 6:592-600.
  • Yu YP, Tseng GC, Luo JH. (2006) Inactivation of myopodin expression associated with prostate cancer relapse. Urology. 68:578-582
  • Jian-Hua Luo, Baoguo Ren, Sergei Keryanov, George C. Tseng, Uma N.M. Rao, Satdarshan P. Monga, Steven Strom, Anthony J. Demetris, Michael Nalesnik, Yan P. Yu, Sarangarajan Ranganathan and George K. Michalopoulos. (2006) Transcriptomic and Genomic analysis of Human Hepatocellular Carcinomas and Hepatoblastomas. Hepatology 44:1012-1024
  • Alejandro Sweet-Cordero, George C. Tseng, Han You, Margaret Douglass, Bing Huey, Todd Golub, Donna Albertson and Tyler Jacks. (2006) Comparison of Gene Expression and Copy Number Changes in a Murine Model of Lung Cancer. Genes, Chromosomes and Cancer. 45:338-348.
  • Baoguo Ren, Guoying Yu, George C. Tseng, Kathleen Cieply, Tim Gavel, Joel Nelson, George Michalopoulos, Yan Ping Yu and Jian-Hua Luo. (2006) MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene. 25:1090-1098.
  • Guoying Yu, George C. Tseng, Yan Ping Yu, Tim Gavel, Joel Nelson, Alan Wells, George Michalopoulos, Demetrius Kokkinakis, and Jian-Hua Luo. (2006) CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer. American Journal of Pathology. 168:597-607.
  • Yingying Huang, Joseph M. Triscari, George C. Tseng, Ljiljana Pasa-Tolic, Mary S. Lipton, Richard D. Smith, Vicki H. Wysocki. (2005) Statistical Characterization of Charge State and Residue Dependence of Low Energy CID Peptide Dissociation Patterns. Analytical Chemistry. 77:5800-5813.
  • Juey-Jen Hwang, Paul D. Allen, George C. Tseng, Ching-Wan Lam, Lameh Fananapazir, Victor J. Dzau, and Choong-Chin Liew. (2002) Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiological Genomics. 10:31-44.
On-going:
  • George C. Tseng. (2008) Visualization of multiple distributions with quantiles and Fisher information with application to tandem mass spectrometry data.
  • Zhibao Mi, Chunrong Cheng, Kui Shen and George C Tseng. Module-based classification method for accurate and robust inter-study prediction in microarray data.
  • Chunrong Cheng, Kui Shen and George C Tseng. Ratio-adjusted gene-wise normalization to enhance classification models for microarray inter-study predictions.
  • Shuya Lu, Jia Li and George C Tseng. Identifying biomarkers of concordant pattern in multiple groups when combining multiple microarray studies.
  • Mamatha Chivukula, Akos Domfeh, Gloria Carter, George C. Tseng, David J. Dabbs. Ductal carcinoma in situ with regressive changes -- recognition and bioprofile.
  • AB Domfeh, A Parwani, M Nikiforova, G Mantha, GC Tseng, M Chivukula. Differentiation from transitional cell carcinomas of bladder using PTEN, WT-1, P16 and p53 markers.
  • Mamatha Chivukula; Anil PArwani; Marina Nikiforova; Geetha Mantha; George C.Tseng,; Kim McManus, Akos Domfeh. Molecular profiles of transitional cell tumors of the ovary. Diagnostic applications and differentiation from transitional cell carcinomas of bladder.
  • Etienne Sibille, Yingjie Wang, Jennifer Joeyen-Waldorf, Chris Gaiteri, Alexandre Surget, Sunghee Oh*, Catherine Belzung, George C Tseng, and David A Lewis. A Phylogenetically-Conserved Molecular Signature of Depression in the Amygdala.
  • RNA Interference against hepatic EGFR has suppressive effects on liver regeneration in rats
Book Review:

  • George C. Tseng (2008) Book Review for "Genomic Signal Processing". Biometrics. 64:10-11.
Study section/grant review:

  • Komen for the Cure Breast Cancer Foundation; study section: Endocrine Therapies. 08/11
  • Review for intramural grants in NIOSH, CDC. (08/09, 08/11)
Books and Book Chapters:

  • Xuewen Chen, George C. Tseng, Xinkun Wang and Anne Zhang. Computational and Statistical Methods in Bioinformatics. Chapman & Hall/CRC. (will publish in 2009) (Amazon)
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  • George C. Tseng. (2006) "Support Vector Machines" and "Classification and Regression Trees". Entries in Encyclopedia of Measurement and Statistics. Sage Publications. (Amazon)
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  • Cheng Li, George C. Tseng, and Wing H. Wong (2003) Model-based analysis of oligonucleotide arrays and issues in cDNA microarray analysis. Book chapter in Statistical analysis of gene expression microarray data. Edited by Terry Speed. CRC Press. 1-34. (Amazon)
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    * students or researchers under my supervision or coordination in the publication.