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Publications
Methodological work:
  1. Jia Li and George C. Tseng. (2010) An adaptively weighted method for combining multiple genomic studies. Annals of Applied Statistics. in revision.
  2. Kui Shen and George C Tseng. (2010) Meta-analysis for pathway enrichment analysis when combining multiple microarray studies. Bioinformatics. in revision.
  3. Shuya Lu, Jia Li, Chi Song, Kui Shen and George C Tseng. (2010) Biomarker Detection in the Integration of Multiple Multi-class Genomic Studies. Bioinformatics. accepted.
  4. George C. Tseng. (2010). Visualization of multiple distributions with quantiles and Fisher information with application to tandem mass spectrometry data. Computational Statistics and Data Analysis. 54:1124-1137.
  5. Chunrong Cheng, Kui Shen, Chi Song, Jianhua Luo and George C Tseng. (2009) Ratio Adjustment and Calibration Scheme for Gene-wise Normalization to Enhance Microarray Inter-study Prediction. Bioinformatics. 25:1655-1661.
  6. George C. Tseng, Chunrong Cheng*, Yan Ping Yu, Joel Nelson, George Michalopoulos and Jian-Hua Luo. (2009) Investigating multi-cancer biomarkers and their cross-predictability in the expression profiles of multiple cancer types. Biomarker Insights. 4:57-79.
  7. Yan Lin, George C. Tseng, Soo Yeon Cheong, Lora J.H. Bean, Stephanie L. Sherman, Eleanor Feingold. (2008) Smarter Clustering Methods for SNP Genotype Calling. Bioinformatics. 24:2665-2671.
  8. Yu-Shuen Tsai, Chin-Teng Lin, George C. Tseng, I-Fang Chung and Nikhil Ranjan Pal. (2008) Discovery of Dominant and Dormant Genes from Expression Data Using a Novel Generalization of SNR for Multi-class Problems. BMC Bioinformatics. 9:425.
  9. Guy N. Brock*, John R. Shaffer*, Richard E. Blakesley-Ball*, Meredith J. Lotz*, and George C. Tseng. (2008) Which Missing Value Imputation Method to Use in Expression Profiles: a Comparative Study and Two Selection Schemes. BMC Bioinformatics. 9:12. (PDF)
  10. Yingying Huang, George C. Tseng, Shinsheng Yuan, Ljiljana Pasa-Tolic, Mary S. Lipton, Richard D. Smith, Vicki H. Wysocki. (2008). A data mining scheme for identifying peptide structural motifs behind different MS/MS fragmentation intensity patterns. Journal of Proteome Research. 7:70-79. (PDF)
  11. George C. Tseng. (2007). Penalized and weighted K-means for clustering with scattered objects and prior information in high-throughput biological data. Bioinformatics. 23:2247-2255. (PDF)
  12. Anbupalam Thalamuthu, Indranil Mukhopadhyay, Xiaojing Zheng and George C. Tseng. (2006) Evaluation and comparison of gene clustering methods in microarray analysis. Bioinformatics. 22:2405-2412. (PDF)(simu data) (real data)
  13. Wei Wu, Nilesh Dave, George C. Tseng, Thomas Richards, Eric Xing, Naftali Kaminski. (2005). Comparison of normalization methods for CodeLink Bioarray data. BMC Bioinformatics. 6:309. (PDF)
  14. George C. Tseng and Wing H. Wong. (2005) Tight Clustering: A Resampling-based Approach for Identifying Stable and Tight Patterns in Data. Biometrics.61:10-16. (PDF) (elected in August 2006 as Fast Breaking Paper in Mathematics by Essential Science Indicators)
  15. Tseng GC (2004) A comparative review of gene clustering in expression profile. Proc. 8th International Conference on Control, Automation, Robotics and Vision (ICARCV). 1320-1324.
  16. Xiaotong Shen, George C. Tseng, Xuegong Zhang, and Wing H. Wong. (2003) On psi-Learning. Journal of the American Statistical Association. 98:724-734. (PDF)
  17. George C. Tseng, Min-Kyu Oh, Lars Rohlin, James C. Liao, and Wing Hung Wong. (2001) Issues in cDNA microarray analysis: quality filtering, channel normalization, models of variations and assessment of gene effects. Nucleic Acids Research. 29: 2549-2557. (PDF) (announced in 2003 as one of the eight most accessed papers in NAR)
Collaborative work:
  1. (with George Michalopoulos) RNA Interference against hepatic EGFR has suppressive effects on liver regeneration in rats. (2010) American Journal of Pathology . accepted
  2. Olga L. Bohn, Irem Nasir, Adam Brufsky, George C Tseng, Rohit Bhargava, Kim MacManus, Mamatha Chivukula. (2010) Biomarker profile in breast carcinomas presenting with bone metastasis. Int J Clin Exp Pathol. 3:139-146.
  3. Sunghee OH, George C. Tseng and Etienne Sibille. (2009) Reciprocal Phylogenetic Conservation of Molecular Aging in Mouse and Human Brain. Neurobiology of Aging . accepted
  4. Marian Rollins-Raval, Mamatha Chivukula, George C. Tseng, Drazen Jukic and David J Dabbs. (2009). An IHC panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature. Archives of Pathology and Laboratory Medicine.
  5. Etienne Sibille, Yingjie Wang, Jennifer Joeyen-Waldorf, Chris Gaiteri, Alexandre Surget, Sunghee Oh, Catherine Belzung, George C Tseng, and David A Lewis. (2009) A Molecular Signature of Depression in the Amygdala. American Journal of Psychiatry. 166:1011-24.
  6. Chivukula M, Bhargava R, Tseng GC and Dabbs DJ. (2009) Clinicopathologic Clinicopathologic implications of "flat epithelial atypia" in core needle biopsy specimens of the breast. American Journal of Clinical Pathology. 131:802-808.
  7. Chivukula M, Domfeh A, Carter G, Tseng GC and Dabbs DJ. (2009) Characterization of High-grade Ductal Carcinoma In Situ With and Without Regressive Changes: Diagnostic and Biologic Implications. Applied Immunohistochemistry & Molecular Morphology. 17(6):495-499.
  8. Han YC, Yu YP, Tseng GC and Luo JH. (2009) Trypsin and reduction method to prepare DNA from formalin-fixed paraffin-embedded samples for methylation analysis. Histopathology. 54:773-775.
  9. Hamm JT, Wilson JW, Rastogi P, Lembersky BC, Tseng GC, Song YK, Kim W, Robidoux A, Raymond JM, Kardinal CG, Shalaby IA, Ansari R, Paik S, Geyer CE, Wolmark N. (2008) Gemcitabine/Epirubicin/Paclitaxel as Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: A Phase II Trial of the NSABP Foundation Research Group. Clinical Breast Cancer. 8:257-263.
  10. Marina N. Nikiforova, George C. Tseng, David Steward, Donna Diorio, and Yuri E. Nikiforov. (2008) MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility. Journal of Clinical Endocrinology & Metabolism 93:1600-1608.
  11. P Limaye, W Bowen, J Luo, GC Tseng, G Michalopoulos.(2008) Mechanisms of HGF and EGF mediated signaling in Transdifferentiation of Rat Hepatocytes to Biliary Epithelium. Hepatology 47:1702-1713.
  12. Alfred Guirguis, Esther Elishaev, Sung-hee Oh, George C. Tseng, Kristin Zorn, Julie A. DeLoia. (2008). Use of Gene Expression Profiles to Stage Concurrent Endometrioid Tumors for the Endometrium and Ovary. Gynecologic Oncology 108:370-376.
  13. Yan Yu, Guoying Yu, George C Tseng, Kathleen Cieply, Joel Nelson, Marie Defrances, Reza Zarnegar, George Michalopoulos and Jianhua Luo. (2007). Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Research. 67:8043-50.
  14. E.Sibille, J.Su, S.Leman, A.M.Le Guisquet, Y.Ibarguen-Vargas, J.Joeyen-Waldorf, C.A. Glorioso, G.C.Tseng, M.Pezzone, R.Hen, C.Belzung. (2007) Reduced longevity and anticipated brain molecular aging in mice lacking the serotonin-1B receptor. Molecular Psychiatry. 12:1042-1056.
  15. Baoguo Ren, Yan Yu, George C. Tseng, Chuanyue Wu, Ka Chen, Uma Rao, Joel Nelson, George Michalopoulos, and Jian-Hua Luo. (2007). Analysis of Integrin alpha-7 Mutations in Prostate Cancer, Liver Cancer, Glioblastoma Multiforme, and Leiomyosarcoma. JNCI. 99:868-80.
  16. C.E. Lagoa, J. Bartels, A. Barratt, G.C. Tseng , G. Clermont, M.P. Fink, T.R. Billiar, Y. Vodovotz. (2006) The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock. 6:592-600.
  17. Yu YP, Tseng GC, Luo JH. (2006) Inactivation of myopodin expression associated with prostate cancer relapse. Urology. 68:578-582
  18. Jian-Hua Luo, Baoguo Ren, Sergei Keryanov, George C. Tseng, Uma N.M. Rao, Satdarshan P. Monga, Steven Strom, Anthony J. Demetris, Michael Nalesnik, Yan P. Yu, Sarangarajan Ranganathan and George K. Michalopoulos. (2006) Transcriptomic and Genomic analysis of Human Hepatocellular Carcinomas and Hepatoblastomas. Hepatology 44:1012-1024
  19. Alejandro Sweet-Cordero, George C. Tseng, Han You, Margaret Douglass, Bing Huey, Todd Golub, Donna Albertson and Tyler Jacks. (2006) Comparison of Gene Expression and Copy Number Changes in a Murine Model of Lung Cancer. Genes, Chromosomes and Cancer. 45:338-348.
  20. Baoguo Ren, Guoying Yu, George C. Tseng, Kathleen Cieply, Tim Gavel, Joel Nelson, George Michalopoulos, Yan Ping Yu and Jian-Hua Luo. (2006) MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene. 25:1090-1098.
  21. Guoying Yu, George C. Tseng, Yan Ping Yu, Tim Gavel, Joel Nelson, Alan Wells, George Michalopoulos, Demetrius Kokkinakis, and Jian-Hua Luo. (2006) CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer. American Journal of Pathology. 168:597-607.
  22. Yingying Huang, Joseph M. Triscari, George C. Tseng, Ljiljana Pasa-Tolic, Mary S. Lipton, Richard D. Smith, Vicki H. Wysocki. (2005) Statistical Characterization of Charge State and Residue Dependence of Low Energy CID Peptide Dissociation Patterns. Analytical Chemistry. 77:5800-5813.
  23. Juey-Jen Hwang, Paul D. Allen, George C. Tseng, Ching-Wan Lam, Lameh Fananapazir, Victor J. Dzau, and Choong-Chin Liew. (2002) Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiological Genomics. 10:31-44.
On-going:
  • Zhibao Mi, Kui Shen, Nan Song, Chunrong Cheng, Chi Song and George C Tseng. (2010) Unsupervised module-based prediction approach for robust inter-study prediction in microarray data.
  • Sunghee Oh, Dongwan Kang, Guy N Brock and George C Tseng. (2010) Biological impacts of missing value imputation on down-stream analyses in microarray data.
  • Xingbin Wang, Sunghee Oh, Etienne Sibille and George C Tseng. (2010) Inferring the true correlation by extreme value correlation analysis in expression profile.
  • Chi Song and George C Tseng. (2010) Vote counting and r-th rank methods for meta-analysis of microarray.
  • Dongwan Kang and George C Tseng. (2010) Meta-analysis in the dimension reduction of microarray data.
  • Dongwan Kang and George C Tseng. (2010) Meta-analysis in the gene clustering of microarray data.
  • Chi Song and George C Tseng. (2010) From meta-analysis to genomic meta-analysis.
  • Mamatha Chivukula, Akos Domfeh, Gloria Carter, George C. Tseng, David J. Dabbs. Ductal carcinoma in situ with regressive changes -- recognition and bioprofile.
  • AB Domfeh, A Parwani, M Nikiforova, G Mantha, GC Tseng, M Chivukula. Differentiation from transitional cell carcinomas of bladder using PTEN, WT-1, P16 and p53 markers.
  • Mamatha Chivukula; Anil PArwani; Marina Nikiforova; Geetha Mantha; George C.Tseng,; Kim McManus, Akos Domfeh. Molecular profiles of transitional cell tumors of the ovary. Diagnostic applications and differentiation from transitional cell carcinomas of bladder.
  • Rollins-Raval MA, Edwards RP, Tseng GC, McManus K and Chivukula M. Immunohistochemical panel to aid in differentiating uterin serous carcinomas from grade 3 endometrial adenocarcinomas.
  • Yi-Kang Shi, Yan P. Yu, George C Tseng and Jian-hua Luo. Inhibition of tumor growth using small interference RNA specific for MCM7.
  • F Gao, G Carter, GC Tseng and M Chivukula. (2009) Clinical importance of histologic grading of lobular Carcinoma in Situ (LCIS) on breast core needle biopsies.
Book Review:
  • George C. Tseng (2008) Book Review for "Genomic Signal Processing". Biometrics. 64:10-11.
Study section/grant review:
  • Komen for the Cure Breast Cancer Foundation; ad hoc member, Endocrine Therapies study section. 2008/11
  • Review for intramural grants in NIOSH, CDC. (2008/09, 2008/11)
  • Komen for the Cure Breast Cancer Foundation; review committee member, Endocrine Therapies study section. 2009-2011
  • NIH Challenge Grants in Health and Science Research, stage 1 expert reviewer. 2009/05
  • NIH; ad hoc member, Genomics, Computational Biology and Technology Study Section (GCAT). 2009/10/14-15
  • DOD DMRDP; ad hoc member, REHAB Panel. 2010/2/7-9
Books and Book Chapters:

  • George C. Tseng. (2006) "Support Vector Machines" and "Classification and Regression Trees". Entries in Encyclopedia of Measurement and Statistics. Sage Publications. (Amazon)
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  • Cheng Li, George C. Tseng, and Wing H. Wong (2003) Model-based analysis of oligonucleotide arrays and issues in cDNA microarray analysis. Book chapter in Statistical analysis of gene expression microarray data. Edited by Terry Speed. CRC Press. 1-34. (Amazon)
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