Research Assistant Professor, Biostatistics

• Education
• Academic and Research Interests
• Selected Publications
• Contact Information

Education

BS, Beijing Normal University, 1994
PhD, University of Michigan, 2001
MS, University of Pittsburgh, 2003
PhD, University of Pittsburgh, 2007

Academic and Research Interests

Statistical genetics, bioinformatics, design and analysis of cancer clinical trials. (Health Sciences Faculty Research Interests Project)

Selected Publications

Wang XB, Lin Y, Song C, Sibille E and Tseng GC. Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: with application to major depressive disorder. BMC Bioinformatics 2012;13(1):52. (PMID: 22458711)

Tarhini AA, Leng S, Moschos S, Yin Y, Sander C, Lin Y, Gooding W, Kirkwood JM. Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. J Immunother 2012;35(4):359-366 (PMID: 22495394).

Zhang Q, Kanterewicz B, Buch S, Parise R, Beumer J, Lin Y, Hershberger PA. CYP24 inhibition preserves 1,25-dihydroxyvitamin D3 anti-proliferative signaling in lung cancer cells. Mol Cell Endocrinol: 2012;355(1):153-161 (PMID: 22386975)

Linkov F, Maxwell GL, Felix AS, Lin Y, Lenzner D, Bovbjerg DH, Lokshin A, Hennon M, Jakicic JM, Goodpaster BH, Delany JP. Longitudinal evaluation of cancer-associated biomarkers before and after weight loss in RENEW study participants: implications for cancer risk reduction. Gynecol Oncol. 2011 Dec. 22[EPUB ahead of print]. (PMID: 22198242).

Torres VE, Grantham JJ, Chapman AB, Mrug M, Bae KT, King BF Jr, Wetzel LH, Martin D, Lockart ME, Bennett WM, Moxey-Mims M, Abebe KZ, Lin Y, Bost JE, for the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2011; 6(3):640-647. (PMID: 21088290)

Ramalignam SS, Kummar S, Sarantopoulos J, Shibata S, Lorusso P, Harvey RD, Yerk M, Lin Y, Beumer JH, Ivy SP, Belani CP, Egorin M. Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: An NCI Oran Dysfunction Working Group (ODWG) study (NCI # 8057). J Clin Oncol 2010; 28(29). (PMID: 20837947)

Shaikh N, Kearney DH, Colborn DK, Balentine T, Feng W, Lin Y, Hoberman A. How do parents of preverbal children with acute otitis media determine how much ear pain their child is having? The Journal of Pain 2010 (In Press) (PMID 2046659)

Hannon T, Lee SJ, Chakravorty S, Lin Y, Arslanian SA. Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance. Int J Pedatr Obes 2010; (In press). (PMID: 20545482)

Jayaram A, Zeevi A, Bentlejewski C, Lin Y, Michaels MG. Immune response of young children using ATP based Cylex Assay: a brief report. Pediatric Transplant 2010; 14 (5): 664-666. (PMID 20345614)

Goyal RK, Lin Y, Livote E, Fairfull L, Yanik G, Ferrell RE, Schultz K, Zorich GP, Atlas M. TNF-a and TNF receptor super family member 1B polymorphisms predict risk of acute AvHG following matched unrelated donor BMT in children: a pediatric blood and marrow transplant consortium study. Biol Blood Marrow Transplantat 2010;16(7):927-936. (PMID 20100586)

Manrique AM, Arroryo M, Lin Y, El Khoudary SR, Colvin E, Lichtenstein S, Chrysostomou C, Orr R, Jooste E, Davis P, Wearden P, Morell V, Munoz R. Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: A randomized controlled study. J Thorac Cardiovasc Surg 2010;139(1):162-169. (PMID 19819469)

O’Malley K, Dhir R, Nelson J, Bost J, Lin Y, Wang Z. The expression of androgen-responsive genes is upregulated in the epithelia of benign prostatic hyperplasia. The Prostates 2009;69(16):1716-1723. (PMID 19676094).

Lin Y, Tseng G, Cheong SY, Bean LJ, Sherman SL, Feingold E. Smarter clustering methods for high-throughput SNP genotype calling. Bioinformatics 2008;24:2665-2671.

Hannon T, Bacha F, Lin Y, Arslanian S. Hyperinsulinemia in African American adolescents compared with their American white peers despite similar insulin sensitivity: a reflection of up-regulated ß-cell function? Diabetes Care 2008;31:1445-1447.

Simon M, Lee MM, Lin Y, Gish L, Schiefelbein J. Distinct and overlapping roles of single-repeat MYB genes in root epidermal patterning. Developmental Biology 2007;311:566-578.

Kelavkar U, Lin Y, Landsittel D, Chandran U, Dhir R. The yin and yang of 15-lipoxygenase-1 and delta-desaturases: dietary omega-6 linoleic acid metabolic pathway in prostate. Journal of Carcinogenesis 2006;5:9.

Ahuja SP, Greenspan SL, Lin Y, Bowen A, Bartels D, Goyal RK. A pilot study of heel ultrasound to screen for low bone mass in children with leukemia. J Pediatr Hematol Oncol 2006 Jul;28(7):427-32

Esposito NN, Mohan D, Brufsky A, Lin Y, Kapali M, Dabbs DJ. Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. Archives of Pathology and Laboratory Medicine 2006;130:1516-1521.

Gerszten K, Gooding WE, Lin Y, Heron DE, Faul C. A single institutional experience with definitive radiotherapy for cervical cancer using both high- and low-dose-rate brachytherapy. Gynecologic Oncology 2006;102:500-507.

Maheshwari V, Tsung A, Lin Y, Zeh HJ, Finkelstein SD, Bartlett DL. Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix. Annals of Surgical Oncology 2006;13:1610-1616.

Zhang X, Chen Z, Choe MS, Lin Y, Sun SY, Wieand HS, Shin HJ, Chen A, Khuri FR, Shin DM. Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Clinical Cancer Research 2005;11:6261-6269.

Mohamed MK, Ramalingam S, Lin Y, Gooding W, Belani CP. Skin rash and good performance status predict improved survival with gefitinib in patients with advanced non–small cell lung cancer. Annals of Oncology 2005;16:780-785.

Lin Y, Feingold E, Reynolds P. An empirical Bayesian method for differential expression studies using one-channel microarray data. Statistical Applications in Genetics and Molecular Biology 2003;2(1):article 8. http://www.bepress.com/sagmb/vol2/iss1/art8/.

Lin Y, Schiefelbein J. Embryonic control of epidermal cell patterning in the root and hypocotyl of Arabidopsis. Development 2001;128:3697-3705.

Hung CY, Lin Y, Zhang M, Pollock S, Marks MD, Schiefelbein J. A common position-dependent mechanism controls cell-type patterning and GLABRA2 regulation in the root and hypocotyl epidermis of Arabidopsis. Plant Physiology 1998;117:73-84.

Contact Information

Sterling Plaza, Suite 325
201 North Criag Street
Pittsburgh, PA 15213
Telephone: 412-383-1311
Facimile:412-383-1535
email: yal14@pitt.edu

Last reviewed: June 18, 2012