Faculty Bio - Doug Potter, PhD
Research Associate Professor, Biostatistics
Research Associate Professor, CTSI
Education
BS, Massachusetts Institute of Technology, 1967
MS, Massachusetts Institute of Technology, 1969
MS, University of Pittsburgh,1998
PhD, Massachusetts Institute of Technology, 1972
Research Interests
Statistical methodology for design and analysis of preclinical studies and early phase clinical trials in cancer; development and use of novel exact and approximate permutation tests; analysis of small datasets.
(Health Sciences Faculty Research Interests Project)
Selected Publications
Butterfield LH, Potter DM, Kirkwood JM. Multiplex serum biomarker assessments: technical and biostatistical issues. Journal of Translational Medicine. 11;9:173, Oct 2011.
Potter DM, Butterfield LH, Divito SJ, Sander CA, Kirkwood JM. Pitfalls in retrospective analyses of biomarkers: A case study with metastatic melanoma patients. Journal of Immunological Methods. 376;108–112, 2012.
Okada H, Kalinski P, Ueda R , Hoji A, Kohanbash G, Donegan TE, Mintz AH, Engh JA, Bartlett DL, Brown CK, Zeh H, Holtzman MP, Reinhart TA, Whiteside TL, Butterfield LH, Hamilton RL, Potter DM, Pollack IF, Salazar AM, Lieberman FS. Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and caraboxymethylcellulose in patients with recurrent malignant glioma. Journal of Clinical Oncology. Jan 20;29(3):330-6, 2011.
Butterfield LH, Palucka AK, Britten CM, Dhodapkar MV, Hakansson L, Janetzki S, Kawakami Y, Kleen TO, Lee PP, Maccalli C, Maecker HT, Maino VC, Maio M, Malyguine A, Masucci G, Pawelec G, Potter DM, Rivoltini L, Salazar LG, Schendel DJ, Slingluff CL Jr, Song W, Stroncek DF, Tahara H, Thurin M, Trinchieri G, van Der Burg SH, Whiteside TL, Wigginton JM, Marincola F, Khleif S, Fox BA, Disis ML. Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clinical Cancer Research. May 15;17(10):3064-3076, 2011.
Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamilton RL, Lotze MT, Khan SA, Sobol RW, Okada H. Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci USA. 106(26):10746-51, 2009.
Ramanathan RK, Egorin MJ, Takimoto CH, Remick SC, Doroshow JH, LoRusso PA, Mulkerin DL, Grem JL, Hamilton A, Murgo AJ, Potter DM, Belani CP, Hayes MJ, Peng B, Ivy SP; National Cancer Institute Organ Dysfunction Working Group. Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group. Journal of Clinical Oncology. 26(4):563-9, 2008.
Singh SV, Powolny AA, Stan SD, Xiao D, Arlotti JA, Warin R, Hahm ER, Marynowski SW, Bommareddy A, Potter DM, Dhir R. Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice. Cancer Research. 68(22):9503-11, 2008.
Potter DM, Robust two-stage model-guided designs for phase I clinical studies (chapter). Wiley Encyclopedia of Clinical Trials. New York, John Wiley & Sons, Inc, 2007.
Potter DM. Phase I studies of chemotherapeutic agents in cancer patients: a review of the designs. Journal of Biopharmaceutical Statistics. 16:579-604, 2006.
Potter, DM. Omnibus Permutation Tests of the Association of an Ensemble of Genetic Markers with Disease in Case-Control Studies. Genetic Epidemiology. 30(5):438-46, 2006.
Potter DM, Griffiths DJ, Omnibus permutation tests of the overall null hypothesis in datasets with many covariates. Journal of Biopharmaceutical Statistics, 16(3):327-341, 2006.
Potter DM. A permutation test for inference in logistic regression with small- and moderate-sized datasets. Statistics in Medicine, 24:693-708, 2005.
Potter, DM. Adaptive Dose Finding for Phase I Clinical Trials of Drugs Used for Chemotherapy of Cancer. Statistics in Medicine, 21:1805-1823, 2002.
Ramanathan, RK, Potter DM, Jacobs SA, Belani CP, Lim F, Kim H, Savona S, Evans T, Buchbarker D, Simon MB, Depee J, Wilson S, Gravenstein S, Trump DL. A randomized trial of influenza vaccine with GM-CSF or placebo in cancer patients. Journal of Clinical Oncology, 21:4313-4318, 2002.
Contact Information
One Sterling Plaza, Suite 325
201 North Craig Street
Pittsburgh, PA 15213
Telephone: 412-383-1580
Facsimile: 412- 383-1535
Email: dmp71@pitt.edu
Last reviewed: May 24, 2012
