Research Assistant Professor, Biostatistics
Biostatistician, UPCI

• Education
• Research Interests
• Selected Publications
• Contact Information

Education

BS, Peking University, 1988
MPH, Peking University, 1994
PhD, Medical College of Wisconsin, 2004

Research Interests

Primary areas of research interest are design and statistical analysis of pre-clinical studies and phase I/II clinical trials, and frailty models in survival analysis. Other areas of interest include in vitro and in vivo radiation survival analysis.

Selected Publications

Wang H, Klein J. Semiparametric Estimation for the Additive Inverse Gaussian Frailty Model. Communications in Statistics—Theory and Methods, 41: 2269–2278, 2012.

Qiu W, Wang H, Zhang L, Yu J. An apoptosis-independent role of SMAC in Tumor Suppression. Oncogene. (Accepted)

Kim H, Bernard ME, Farkas A, Goff J, Kalash R, Houghton F, Shields D, Franicola D, Dixon T, Zhang X, Epperly M, Wang H, Cobanoglu MC, Greenberger JS. Ionizing Irradiation Protection and Mitigation of Murine Cells by Carbamazepine is p53 and Autophagy Independent. In Vivo. 2012 May;26(3):341-54.

O'Sullivan R, Greenberger JS, Goff J, Cao S, Kingston KA, Zhou S, Dixon T, Houghton FD, Epperly MW, Wang H, Glowacki J. Dysregulated in vitro Hematopoiesis, Radiosensitivity, Proliferation, and Osteoblastogenesis with Marrow from SAMP6 Mice. Exp Hematol. 2012 Feb 8. [Epub ahead of print]

Bernard ME, Kim H, Rajagopalan MS, Stone B, Salimi U, Rwigema JC, Epperly MW,Shen H, Goff JP, Franicola D, Dixon T, Cao S, Zhang X, Wang H, Stolz DB, Greenberger JS. Repopulation of the irradiation damaged lung with bone marrow-derived cells. In Vivo. 2012 Jan-Feb;26(1):9-18.

Kim H, Bernard ME, Epperly MW, Shen H, Amoscato A, Dixon TM, Doemling AS, Li S, Gao X, Wipf P, Wang H, Zhang X, Kagan VE, Greenberger JS. Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In Vivo. 2011 Nov-Dec;25(6):841-8.

Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497.

Rajagopalan MS, Stone B, Rwigema JC, Salimi U, Epperly MW, Goff J, Franicola D, Dixon T, Cao S, Zhang X, Buchholz BM, Bauer AJ, Choi S, Bakkenist C, Wang H, Greenberger JS. Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice. Radiat Res. 2010 Sep; 174(3):297-312.

Wang H. Sign Test. Encyclopedia of Research Design. 2010. Edited by Neil J. Salkind, Sage Publications, Newbury Park, CA.

Lo SS, Khorana AA, Javle M, Simon S, Kiefer G, Rajasenan K, Wang H, Hantel A, Shayne M, Hwang J, Schmotzer A, Ramanathan RK. A phase II study of weekly docetaxel in combination with capecitabine in advanced gastric and gastroesophageal adenocarcinomas. Oncology. 2010; 78(2):125-9.

Epperly MW, Melendez JA, Zhang X, Nie S, Pearce L, Peterson J, Franicola D, Dixon T, Greenberger BA, Komanduri P, Wang H, Greenberger JS. Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo. Radiat Res. 2009 May; 171(5):588-95.

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS. Lack of DNA Polymerase theta (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation. Radiat Res. 2009 Aug; 172(2):165-74.

Wang W, Edington HD, Rao UN, Jukic DM, Radfar A, Wang H, Kirkwood JM. Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clin Cancer Res. 2008 Dec 15; 14(24):8314-20.

Epperly MW, Smith T, Wang H, Schlesselman J, Franicola D, Greenberger JS. Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiation Research. 2008; Oct; 170(4):437-43.

Oton AB, Wang H, Leleu X, Melhem MF, George D, Lacasce A, Foon K, Ghobrial IM. Clinical and Pathological Prognostic Markers for Survival in Adult Patients with Post-Transplant Lymphoproliferative Disorders. Leukemia and Lymphoma. September 2008, 49(9):1738-1744.

Wang W, Edington HD, Rao UN, Jukic DM, Wang H, Shipe-Spotloe JM, Kirkwood JM. STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: dose-response effects of systemic IFNalpha therapy. J Invest Dermatol. 2008 Aug; 128(8):1997-2002.

Niu Y, Epperly M, Shen H, Smith T, Wang H, Greenberger J. Intraesophageal MnSOD-Plasmid Liposome Administration Enhances Engraftment and Self-Renewal Capacity of Bone Marrow Derived Progenitors of Esophageal Squamous Epithelium. Gene Therapy. 2008 Mar; 15(5):347-56.

Logan B, Wang H, Zhang M. Pairwise Multiple Comparison Adjustment in Survival Analysis. Statistics in Medicine. 24 (16): 2509-2523, Aug 30 2005

Contact Information

Suite 325 Sterling Plaza
201 North Craig Street
Pittsburgh, PA 15213
Telephone: 412-383-1588
Facsimile: 412-383-1535
Email: how8@pitt.edu

Last reviewed: June 7, 2012